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Effect of metabolic syndrome and aging on Ca2+ dysfunction in coronary smooth muscle and coronary artery disease severity in Ossabaw miniature swine.
CONCLUSIONS: Ca2+ dysregulation, mainly the SR Ca2+ store, in CSM is more pronounced in lean old compared to both MetS groups, which is indicative of mild, proliferative CAD. MetS old and MetS young swine exhibit Ca2+ dysfunction that is typical of late, severe disease. The more advanced, complex plaques in MetS old swine suggest that the "aging milieu" potentiates effects of Ca2+ handling dysfunction in CAD.
PMID: 29730333 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - May 3, 2018 Category: Geriatrics Authors: Badin JK, Bruning RS, Sturek M Tags: Exp Gerontol Source Type: research
Classical swine fever: challenges for the emerging swine sector in Bhutan
AbstractGiven the importance of pork in the Bhutanese diet and to enhance food security, the Government of Bhutan has generated policies to promote development of the swine sector in the country. One of the main threats to swine farming is classical swine fever (CSF), a transboundary disease of wild and domestic swine thought to be enzootic in the country. In 2018, three outbreaks of CSF were notified in Bhutan. The type of animals, their vaccine status, and the aftermath of these outbreaks highlight the interplay of epidemiological and context-specific factors that may result in CSF undermining the emerging Bhutanese swin...
Source: Tropical Animal Health and Production - March 15, 2020 Category: Veterinary Research Source Type: research
High Fat, High Fructose, High Cholesterol Feeding Causes Severe NASH and Cecal Microbiota Dysbiosis in Juvenile Ossabaw Swine.
Abstract
Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal model. Here, we examined the effects of high fat, high fructose corn syrup, high cholesterol Western style diet (WD)-induced obesity on NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Juvenile female Ossabaw swine (5 weeks old) were fed WD (43.0% fat; 17.8% high fructose corn syrup; 2% cholesterol) or low-fat diet (CON/lean; 10.5% fat) for 16 wks (n=6 each) or 36 wks (n=4 each). WD...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 12, 2017 Category: Physiology Authors: Panasevich MR, Meers GM, Linden MA, Booth FW, Perfield JW, Fritsche KL, Wankhade UD, Chintapalli SV, Shankar K, Ibdah JA, Rector RS Tags: Am J Physiol Endocrinol Metab Source Type: research
Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia
This study reveals that MetS and ischemia diminishes ATP availability in the myocardium via altering t he glucose-G6P-pyruvate axis at the level of metabolites and gene expression of related enzymes. The observed severe glycogen depletion in MetS coincides with disbalance in expression of GYS1 and both PYGM and PYGL. This altered energy substrate metabolism is a potential target of pharmacological ag ents for improving juvenile myocardial function in MetS and ischemia.
Source: Physiological Reports - August 4, 2023 Category: Physiology Authors: Mark Broadwin,
Dwight D. Harris,
Sharif A. Sabe,
Elif Sengun,
Amber J. Sylvestre,
Boian S. Alexandrov,
Frank W. Selke,
Anny Usheva Tags: ORIGINAL ARTICLE Source Type: research
Subacute Cadmium Exposure Induces Necroptosis in Swine Lung via Influencing Th1/Th2 Balance
Biol Trace Elem Res. 2022 Feb 3. doi: 10.1007/s12011-022-03133-6. Online ahead of print.ABSTRACTCadmium (Cd) is a type of toxic substance, which widely exists in nature. However, the effect of Cd exposure on the toxicity of swine lungs and its underlying mechanism involved have not yet been reported. In our study, we divided swine into two groups, including a control group (C group) and Cd-exposed group. Swine in the C group were fed a basic diet, whereas swine in the Cd group were fed a 20 mg Cd/kg diet. Immunofluorescence, qRT-PCR, western blot analysis, and H&E staining were performed to detect necroptosis-related i...
Source: Biological Trace Element Research - February 4, 2022 Category: Biology Authors: Wenyue Zhang Xinyue Sun Xu Shi Xue Qi Shaoqian Shang Hongjin Lin Source Type: research
Cardiovascular Parameters in a Swine Model of Normobaric Hypoxia Treated With 5-Hydroxymethyl-2-Furfural (5-HMF)
Conclusion: 5-HMF treatment decreased P50, improved SaO2, and mitigated increases in PAP in this swine model of NH.
Introduction
The reduction of barometric pressure at altitude is associated with reduced partial pressure of ambient Oxygen (PO2). With lower ambient PO2, it can be anticipated that alveolar (PAO2), arterial O2 (PaO2) and blood O2 content (CaO2) will decrease accordingly, resulting in a widely recognized decrease in maximal O2 consumption (VO2) (Dill and Adams, 1972; Lucas et al., 2011). In humans, with acute exposure to altitude, maximal VO2 decrements are measurable at elevations even as low as 580 ...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research
Effect of Age on Diabetogenicity of Alloxan in Ossabaw Miniature Swine.
This study supports previous research that the effects of alloxan are dependent on the developmental maturity of the animal.
PMID: 30894246 [PubMed - as supplied by publisher]
Source: Comparative Medicine - March 19, 2019 Category: Zoology Authors: Badin JK, Progar V, Pareddy A, Cagle J, Alloosh M, Sturek M Tags: Comp Med Source Type: research
Cadmium Exposure Induces TNF- α-Mediated Necroptosis via FPR2/TGF-β/NF-κB Pathway in Swine Myocardium
Toxicology. 2021 Feb 21:152733. doi: 10.1016/j.tox.2021.152733. Online ahead of print.ABSTRACTCadmium (Cd) is one common environmental pollutant with systemic toxicity. Lipoxin A4 (LXA4) can regulate transforming growth factor-β (TGF-β) pathway and alleviate tissue injury via binding to formyl peptide receptor 2 (FPR2). The activation of nuclear factor-κB (NF-κB) pathway can promote the occurence of necroptosis. However, whether Cd exposure induces necroptosis in swine myocardium and the role of FPR2/TGF-β/NF-κB signaling in this process are unclear. Hence, we established Cd-exposed swine myocardial injury model by f...
Source: Toxicology - February 24, 2021 Category: Toxicology Authors: Xia Zhao Shengchen Wang Xiaojing Li Honggui Liu Shiwen Xu Source Type: research
TRAF2/ASK1/JNK Signaling Pathway Is Involved in the Lung Apoptosis of Swine Induced by Cadmium Exposure
Biol Trace Elem Res. 2021 Aug 8. doi: 10.1007/s12011-021-02860-6. Online ahead of print.ABSTRACTCadmium (Cd), a toxic heavy metal, exists widely in the environment, which can enter organisms through a variety of ways and cause damage to various organs and tissues. However, the mechanism of lung toxicity in swine after Cd exposure is still unclear. To explore the molecular mechanism of swine lung damage caused by Cd exposure, we established the model of Cd exposure, and Cd chloride (20 mg/kg CdCl2) was added to the diet of swine for continuous exposure for 40 days. TUNEL staining showed that the apoptosis of swine lung incr...
Source: Biological Trace Element Research - August 8, 2021 Category: Biology Authors: Jinxi Zhang Yue Zhang Xue Qi Yuan Cui Xiaoming Chen Hongjin Lin Source Type: research
